Acetone → HCID 178440085, compound

Participants

Reaction Steps

5.0 grams of 4,4-dimethyl-2-propyl-4,6-dihydrofuro[3,4-d]imidazole (formula II) from Example 1, 30 ml of acetone and 50 ml of 10% sodium hydroxide solution were added into 250 ml eggplant flask and refluxed until the reaction completed. Part of the solvent was removed by evaporation, and then the reactant was adjusted to acidic by dropwise addition of concentrated hydrochloric acid. The precipitation was filtered, collected and dried to give 5.3 grams of 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid (formula III), resulting in a yield of 96%.

Provenance & Evidence