HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malic Acid → Sunitinib Malate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malic Acid | HCID 525 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sunitinib | HCID 5329102 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Sunitinib Malate | HCID 6456015 | 77.2% |
Reaction Steps
1 g of sunitinib base was suspended in 4 ml of DMSO, at RT. 0.336 g of Malic acid added (as a solid) obtaining a solution, then 20 ml of ethyl acetate were added drop wise and precipitation was observed. The suspension was kept at 20-25° C. for 1 hour then filtered and washed with ethyl acetate. Dried at 80° C. under vacuum for 16-18 h affording 1.03 g of Sunitinib Malate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618309B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-38b797fd3e494780abccc99086bdc99c |
| Source note | uspto-grants-2013_12 |