Acetic Acid → HCID 86653606, compound

Participants

Reaction Conditions

Reaction Steps

Sunitinib base (4 g) was suspended in n-butanol (12 ml) with stirring at 20-25° C. Then 1.05 eq (0.45 ml) of acetic acid were added observing dissolution and after 1-2′ precipitation of an orange solid. Then methyl tert-butyl ether (80 ml) was added at 20-25° C. within 10 min with stirring, the mixture was cooled to −10° C. in 2 hours. After 16 h at −10° C. the solid was filtered, washed with 2×20 ml of MTBE and dried on the filter for 1 h yielding 4 g of Sunitinib Acetate.

Provenance & Evidence