Acetic Acid → HCID 86653606, compound

Participants

Reaction Conditions

Reaction Steps

Sunitinib base (10 g, 0.025 mol) was suspended in 1-butanol (70 ml) with stirring at 20° C., then 1.05 eq (1.54 ml) of acetic acid were added observing dissolution and after about 5 minutes precipitation of an orange solid. The mixture was heated to 60° C. and methyl tert-butyl ether (200 ml) was added at 60° C. within 40 min with stirring, the mixture was cooled to −10° C. in 2 hours. After 16 h at −10° C. the solid was filtered, washed with 2×20 ml of MTBE and dried on filter for 1 h. 10.8 g of Sunitinib Acetate (94% yield) was thus obtained.

Provenance & Evidence