3-Methylbenzeneethanol → 1-[4-Acetyl-3-(2-m-tolyl-ethoxy)-benzoylamino]-cycloheptanecarboxylic acid methyl ester

HRID 1918295Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1([NH:12][C:13](=[O:24])[C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:22])[CH3:21])=[C:16]([OH:23])[CH:15]=2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4].[C:25]1([CH3:34])[CH:30]=[CH:29][CH:28]=[C:27]([CH2:31][CH2:32]O)[CH:26]=1>>[CH3:1][O:2][C:3]([C:5]1([NH:12][C:13](=[O:24])[C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:22])[CH3:21])=[C:16]([O:23][CH2:32][CH2:31][C:27]3[CH:26]=[C:25]([CH3:34])[CH:30]=[CH:29][CH:28]=3)[CH:15]=2)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)=[O:4]

Participants

Reactant 2

HCID 746483-Methylbenzeneethanol

HCID 671697031-(4-Acetyl-3-hydroxy-benzoylamino)-cycloheptanecarboxylic Acid Methyl Ester

Product 1

HCID 708721291-[4-Acetyl-3-(2-m-tolyl-ethoxy)-benzoylamino]-cycloheptanecarboxylic acid methyl ester

Procedure

The compound of step 1 and 2-m-tolylethanol were reacted in analogy to step 1 of example 1 to yield the title compound.

Sources & evidence

ORD record: ord-f950dd8f3575429f8b34eb5cc86c875c
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08618304B2

Reaction notes

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