反应详情

The compound of step 1 (200 mg, 0.932 mmol) was dissolved in DCM (16 ml), DMF (12 mg) and oxalyl chloride (362 mg, 2.80 mmol) were added and the mixture was stirred at room temperature until completion of the reaction. The volatiles were evaporated in vacuo and the residue dissolved in DCM. The solution was added to a stirred mixture of 1-amino-cycloheptanecarboxylic acid methyl ester hydrochloride (194 mg, 0.932 mmol) in EA/saturated sodium hydrogencarbonate solution with cooling in an ice bath. Stirring continued at room temperature for 2 h. The phases were separated, aqueous phase was extracted with EA, the combined organic phases were dried over sodium sulfate and evaporated to dryness. The residue was purified by silica gel chromatography (HEP/EA gradient) to yield the title compound (430 mg).

1. customThe volatiles were evaporated in vacuo
2. dissolutionthe residue dissolved in DCM
3. temperaturewith cooling in an ice bath
4. stirringStirring
5. customThe phases were separated
6. extractionaqueous phase was extracted with EA
7. dry with materialthe combined organic phases were dried over sodium sulfate
8. customevaporated to dryness
9. customThe residue was purified by silica gel chromatography (HEP/EA gradient)