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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1918300Generated: November 2, 2026

Potassium Carbonate → 1-(4-Chloro-3-hydroxy-benzoylamino)-cycloheptanecarboxylic acid methyl ester

https://huagongshe.com/reaction/1918300

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant1-(3-Acetoxy-4-chloro-benzoylamino)-cycloheptanecarboxylic Acid Methyl EsterHCID 67170879—
SolventMethanolHCID 887—
Product1-(4-Chloro-3-hydroxy-benzoylamino)-cycloheptanecarboxylic acid methyl esterHCID 6717038484.6%

Reaction Steps

The compound of step 2 (400 mg, 1.088 mmol) was dissolved in methanol (3.5 ml), potassium carbonate (3 mg, 0.02 mmol) was added, and the mixture was stirred at room temperature for 6 h and evaporated to dryness to yield the title compound (300 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08618304B2
Source datasetuspto-grants-2013_12
ORD IDord-b6cde11a3da344d3819d60dcbe44e958
Source noteuspto-grants-2013_12