HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67170252, compound → HCID 67169865, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67170252 | HCID 67170252 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Palladium | HCID 23938 | — |
| Solvent | HCID 178418361 | HCID 178418361 | — |
| Product | HCID 67169865 | HCID 67169865 | — |
Reaction Steps
Diastereomer 1 and diastereomer 2 of the compound of example 66 were separately dissolved in ethanol and hydrogenated with palladium 10% on charcoal at room temperature with 1 bar hydrogen pressure until completion of the reaction. After filtration, the solutions were evaporated to dryness and the residues purified by RP HPLC (water/ACN gradient) to yield the two diastereomers of the title compound separately.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618304B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-4225b81eaec4410ba8f5ac8d71251e15 |
| Source note | uspto-grants-2013_12 |