HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1918312Generated: October 31, 2026
Methanol → 5-Bromo-6-methoxy-3-pyridinecarboxylic acid
https://huagongshe.com/reaction/1918312
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 5-bromo-6-methoxypyridine-3-carboxylate | HCID 46311221 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Bromo-6-methoxy-3-pyridinecarboxylic acid | HCID 45790466 | — |
Reaction Steps
5-Bromo-6-methoxy-nicotinic acid methyl ester (W. J. Thompson et al., J. Org. Chem. 49 (1984), 5237-5243; 2.00 g, 8.13 mmol) was dissolved in dioxane (40 ml), lithium hydroxide (40 ml of a 1 M solution in water) was added and subsequently sufficient methanol to achieve complete dissolution. The mixture was stirred at 60° C. for 2 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618304B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-97baeb2699174942a3eed506997b79bf |
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| Source note | uspto-grants-2013_12 |
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