Methanol → HCID 67170305, compound

HRID 1918321Notes

Reaction equation

HRID 1918321 reaction equation
[NH2:1][C:2]1([C:9]([OH:11])=[O:10])[CH2:7][CH:6]2[O:8][CH:3]1[CH2:4][CH2:5]2.S(Cl)(Cl)=O.[CH3:16]O>>[CH3:16][O:10][C:9]([C:2]1([NH2:1])[CH2:7][CH:6]2[O:8][CH:3]1[CH2:4][CH2:5]2)=[O:11]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 19752095HCID 19752095, compound

Product 1

HCID 67170305HCID 67170305, compound

Procedure

3.0 g of 2-amino-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid were suspended in 100 ml of methanol and 11.4 g of thionyl chloride were added at room temperature. The mixture was left at room temperature for 24 h. Then the volatiles were evaporated in vacuo to yield 3.9 g of the title compound as a racemic mixture.

Workup

  1. customThen the volatiles were evaporated in vacuo

Sources & evidence

ORD record
ord-2ebf17be262a4955947ea106ac396ba6
Source dataset
uspto-grants-2013_12
Patent number
US08618304B2

Reaction notes

Loading…