HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenylboronic acid → 5-Fluoro-6-(2-hydroxy-ethoxy)-3'-trifluoromethyl-biphenyl-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenylboronic acid | HCID 2734388 | — |
| Reactant | 4-(2-Acetoxy-ethoxy)-3-bromo-5-fluoro-benzoic Acid Methyl Ester | HCID 67170618 | — |
| Product | 5-Fluoro-6-(2-hydroxy-ethoxy)-3'-trifluoromethyl-biphenyl-3-carboxylic acid | HCID 67169264 | — |
Reaction Steps
The compound of step 1 was coupled to 3-trifluoromethyl-phenylboronic acid in analogy to step 3 of example 92, and the obtained ester intermediate was hydrolyzed in analogy to step 4 of example 1 to yield 5-fluoro-6-(2-hydroxy-ethoxy)-3′-trifluoromethyl-biphenyl-3-carboxylic acid. This intermediate was coupled to the compound of step 1 of example 355 in analogy to step 1 of example 3, and the obtained ester intermediate hydrolyzed in analogy to step 4 of example 1 to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618304B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-32bb1a909d654a15a990ebc804cf706f |
| Source note | uspto-grants-2013_12 |