HCID 67169809, compound → HCID 67170979, compound

HRID 1918349Notes

Reaction equation

HRID 1918349 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)[C:8]([CH:11]=[CH:12][C:13]([OH:15])=[O:14])=[CH:9][CH:10]=1)=[O:4].[H][H]>CO.[Pd]>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:23])([F:25])[F:24])[CH:17]=2)[C:8]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[CH:9][CH:10]=1)=[O:4]

Participants

5

Reactant 2

HCID 67169809HCID 67169809, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67170979HCID 67170979, compoundYield 92.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The compound of step 1 (400 mg, 1.14 mmol) and Palladium (10%) on charcoal (23 mg) were suspended in methanol (30 ml). The mixture was hydrogenated for 3 h at 4 bar hydrogen pressure, subsequently filtered over Celite and evaporated to dryness to yield the title compound (372 mg).

Workup

  1. filtrationsubsequently filtered over Celite
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-de0a5414b70e4be59a1c66e2b6a5eed4
Source dataset
uspto-grants-2013_12
Patent number
US08618304B2

Reaction notes

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