Potassium Carbonate → HCID 67170195, compound

Participants

Reaction Conditions

Reaction Steps

150 mg of 3-Bromo-4-(3,3-difluoro-cyclobutoxy)-benzoic acid methyl ester, 113 mg of 3-chloro-4-methoxyphenylboronic acid, 129 mg K2CO3, 10 mg of palladium(II)acetate, and 25 mg of triphenylphosphine were dissolved using 10 ml of DMF and 0.5 ml of water. The reaction mixture was stirred at 120° C. for 2 h, then cooled to room temperature, 50 ml of water added and extracted three times using 30 ml of EA each. The organic layer was dried using MgSO4 and volatiles were evaporated. Chromatography on silica gel using EA/HEP 1:5 yielded 90 mg of the title compound, viscous oil.

Provenance & Evidence