HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Methyl 3-bromo-5-fluoro-4-methoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 57467610 | HCID 57467610 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Methyl 3-bromo-5-fluoro-4-methoxybenzoate | HCID 67076673 | 37.9% |
Reaction Steps
5.0 g of 3-Bromo-5-fluoro-4-hydroxy-benzoic acid methyl ester were dissolved using 50 ml of acetone. Then, 8.3 g of K2CO3 and 2.5 ml of CH3I were added and the reaction mixture stirred at room temperature for 48 h. The reaction mixture was then filtrated and evaporated. Chromatography on silica gel using EA/HEP 1:2 yielded 2.0 g of the title compound, oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618304B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-b685a36fd2da4f019ebe9fc78198d11a |
| Source note | uspto-grants-2013_12 |