Methyl 1-aminocycloheptanecarboxylate → 1-[(6-Methoxy-3'-oxetan-3-yl-biphenyl-3-carbonyl)-amino]-cycloheptanecarboxylic Acid Methyl Ester

HRID 1918378Notes

Reaction equation

HRID 1918378 reaction equation
[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]3[CH2:18][O:17][CH2:16]3)[CH:10]=2)=[CH:7][C:6]([C:19](O)=[O:20])=[CH:5][CH:4]=1.[CH3:22][O:23][C:24]([C:26]1([NH2:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)=[O:25]>>[CH3:22][O:23][C:24]([C:26]1([NH:33][C:19]([C:6]2[CH:7]=[C:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]4[CH2:18][O:17][CH2:16]4)[CH:10]=3)[C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[O:20])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]1)=[O:25]

Participants

3

Reactant 2

HCID 1512631Methyl 1-aminocycloheptanecarboxylateHCID 671695046-Methoxy-3'-oxetan-3-yl-biphenyl-3-carboxylic acid

Product 1

HCID 671694121-[(6-Methoxy-3'-oxetan-3-yl-biphenyl-3-carbonyl)-amino]-cycloheptanecarboxylic Acid Methyl Ester

Procedure

The title compound was synthesized from 6-Methoxy-3′-oxetan-3-yl-biphenyl-3-carboxylic acid and 1-amino-cycloheptanecarboxylic acid methyl ester in analogy to example 126, step 4.

Sources & evidence

ORD record
ord-cca32e0f42d340cab284ebfef66f6124
Source dataset
uspto-grants-2013_12
Patent number
US08618304B2

Reaction notes

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