反应详情

Benzyl N-phenylpropynthioimidate (0.30 g) and 4-fluorobenzylmercaptan were dissolved to chloroform (15 ml), catalytic amount of potassium t-butoxide was added thereto under ice-cooling and stirred at room temperature for 14 hours. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=15:1) to obtain benzyl 3-(4-fluorobenzylthio)-N-phenyl-thioacrylimidate (0.15 g) as light yellow oil.

1. additionwas added
2. temperatureunder ice-cooling
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=15:1)