反应详情

The mixture of ethyl 4-methyl-2-p-tolylthiazole-5-carboxylate (0.200 g; 0.765 mmol) and sodium hydroxide (0.0643 g; 1.61 mmol) in water (4 mL) and ethanol (8 mL) was irradiated in a microwave oven at 130° C. for 5 min. The mixture was concentrated (removal of ethanol), and the pH of the solution was adjusted to 3 by addition of 6N hydrochloric acid. The acidic solution was extracted with (3×10 mL) of ethyl acetate. Combined organic layers were dried over magnesium sulfate, and evaporated to afford 0.157 g (88%) of 4-methyl-2-p-tolylthiazole-5-carboxylic acid as a white solid which was directly used in the next step.

1. customwas irradiated in a microwave oven at 130° C. for 5 min
2. concentrationThe mixture was concentrated
3. custom(removal of ethanol)
4. additionthe pH of the solution was adjusted to 3 by addition of 6N hydrochloric acid
5. extractionThe acidic solution was extracted with (3×10 mL) of ethyl acetate
6. dry with materialCombined organic layers were dried over magnesium sulfate
7. customevaporated