HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyaniline → 1-(2-Methoxyphenyl)-2-oxo-3-pyrrolidinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyaniline | HCID 7000 | — |
| Reactant | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(2-Methoxyphenyl)-2-oxo-3-pyrrolidinecarboxylic acid | HCID 4344448 | 101.2% |
Reaction Steps
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g, 1.47 mmol) and 2-methoxyaniline (0.495 mL; 4.41 mmol) in ethanol (3 mL). 1-(2-methoxyphenyl)-2-oxopyrrolidine-3-carboxylic acid 0.350 g (quantitative) was obtained as a grey solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618138B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-c8b36939fafb4cc29cc906a33c56d079 |
| Source note | uspto-grants-2013_12 |