6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → HCID 66832060, compound

HRID 1918569Notes

Reaction equation

HRID 1918569 reaction equation
CC1(C)[O:9][C:8](=[O:10])[C:5]2([CH2:7][CH2:6]2)[C:4](=[O:11])O1.[CH3:13][N:14]1[CH:18]=[CH:17][C:16]([NH2:19])=[N:15]1>C(O)C>[CH3:13][N:14]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:6][CH2:7][CH:5]([C:8]([OH:9])=[O:10])[C:4]2=[O:11])=[N:15]1

Participants

4

Reactant 2

HCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dioneHCID 1372541-Methyl-3-aminopyrazole

Product 1

HCID 66832060HCID 66832060, compoundYield 21%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g, 1.47 mmol) and 1-methyl-1H-pyrazol-3-amine (0.428 g; 4.41 mmol) in ethanol (3 mL). 1-(1-methyl-1H-pyrazol-3-yl)-2-oxopyrrolidine-3-carboxylic acid 0.063 g (21%) was obtained as a yellow oil.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-3a6f3c156c98403696fd61ccc227c566
Source dataset
uspto-grants-2013_12
Patent number
US08618138B2

Reaction notes

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