HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluoroaniline → 1-(2,6-Difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluoroaniline | HCID 79647 | — |
| Reactant | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(2,6-Difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid | HCID 24275252 | 46% |
Reaction Steps
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 2,6-difluoroaniline (0.575 g; 4.36 mmol) in ethanol (3 mL). 1-(2,6-difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid 0.161 g (46%) was obtained as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618138B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-a861d4c0128e4b7092263e45227a8952 |
| Source note | uspto-grants-2013_12 |