HRID1918679
反应详情
EQUATION
反应方程式
REACTANTS
反应物
HCID6228
N,N-Dimethylformamide
C3H7NO
HCID8857
Ethyl acetate
C4H8O2
HCID81531
Diisopropylethylamine
C8H19N
HCID2827494
5-Chloro-1H-indole-3-ethylamine monohydrochloride
C10H12Cl2N2
HCID9886157
Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
C10H15F6N6OP
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
This compound was prepared following Method A starting from 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.100 g; 0.424 mmol), intermediate 20 (5-cyclohexylisoxazole-3-carboxylic acid) (0.087 g; 0.445 mmol), HATU (0.177 g; 0.466 mmol) and N,N-diisopropylethylamine (0.185 mL; 1.06 mmol) in DMF (3 mL). Flash chromatography on silica gel eluting with 7 to 60% of ethyl acetate in heptane gave 0.079 g (50%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-5-cyclohexylisoxazole-3-carboxamide as a solid.
WORKUP
后处理
- customThis compound was prepared