HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1918871Generated: October 31, 2026
Dimethyl Sulfoxide → 1-Ethyl-4-(6-nitropyridin-3-yl)piperazine
https://huagongshe.com/reaction/1918871
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Ethylpiperazine | HCID 79196 | — |
| Reactant | 5-Bromo-2-nitropyridine | HCID 817620 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Ethyl-4-(6-nitropyridin-3-yl)piperazine | HCID 57502086 | — |
Reaction Steps
To a sealed tube equipped with a stirring bar, 5-bromo-2-nitropyridine (3.00 g, 14.78 mmol), 1-ethylpiperazine (5.06 g, 44.34 mmol), tetrabutylammonium iodide (273 mmol, 0.739 mmol), K2CO3 (6.128 g, 44.34 mmol), and DMSO (30 mL) were added. The tube was sealed and heated at 90° C. overnight. Water (200 mL) was added and the precipitation was filtered to afford 138a as a yellow solid, 1.24 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618107B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-d7f207ea6b8449cc8ded7d5adb697fd0 |
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| Source note | uspto-grants-2013_12 |
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