1-Ethyl-4-(6-nitropyridin-3-yl)piperazine → 5-(4-Ethylpiperazin-1-yl)pyridin-2-amine

Participants

Reaction Steps

In a hydrogenation bottle, 138a (2.59 g, 10.96 mmol), EtOH (100 mL), 10% Pd/C (580 mg, 0.55 mmol) were added. The mixture was hydrogenated at 55 psi for 2 hrs, and then filtered through celite and washed with MeOH (20 mL). The solvent was removed in vacuo and pink solids were obtained as 138b (2.51 g, 82%).

Provenance & Evidence