5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridin-2-amine → 5-Bromo-1-methyl-3-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-ylamino)pyridin-2(1H)-one

HRID 1918877Notes

Reaction equation

HRID 1918877 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2[N:8]=[C:9]([NH2:11])[S:10][C:4]=2[CH2:3]1.Br[C:13]1[C:14](=[O:21])[N:15]([CH3:20])[CH:16]=[C:17]([Br:19])[CH:18]=1>>[Br:19][C:17]1[CH:18]=[C:13]([NH:11][C:9]2[S:10][C:4]3[CH2:3][N:2]([CH3:1])[CH2:7][CH2:6][C:5]=3[N:8]=2)[C:14](=[O:21])[N:15]([CH3:20])[CH:16]=1

Participants

3

Reactant 2

HCID 23979985-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridin-2-amineHCID 36143503,5-Dibromo-1-methylpyridin-2(1H)-one

Product 1

HCID 580436615-Bromo-1-methyl-3-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-ylamino)pyridin-2(1H)-oneYield 52.6%

Procedure

Following Example 110c, 3 g of 141a and 4 g of 3,5-dibromo-1-methylpyridin-2(1H)-one were reacted to give 141b as a yellow solid (2.8 g, 52%). LCMS: [M+H]+ 357

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-464bf311da2440eb9e3386caac876a18
Source dataset
uspto-grants-2013_12
Patent number
US08618107B2

Reaction notes

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