HRID1918882
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 130 °C
PROCEDURE
实验过程
A 25 mL vial was charged with 143a (238 mg, 0.7 mmol), 2-bromo-4-fluoro-6-(1-oxo-3,4,6,7,8,9-hexahydro-pyrazino[1,2-a]indol-2(1H)-yl)benzyl acetate 197d (300 mg, 0.7 mmol), Na2CO3 (147 mg, 1.4 mmol), PdCl2(dppf) (56 mg, 0.07 mmol) suspended in DME (15 mL), and H2O (1 mL). The resulting orange mixture was heated for 30 minutes in a Biotage microwave reactor at 130° C. After reaction the residue was purified by reverse phase Combi-flash eluting with 0.3% NH4HCO3 in 1:7 water/CH3CN to give 143b as a brown solid (150 mg, 33%). MS: (M+H)+ 656.
WORKUP
后处理
- customAfter reaction the residue
- customwas purified by reverse phase Combi-flash
- washeluting with 0.3% NH4HCO3 in 1:7 water/CH3CN