反应详情

To a microwave tube equipped with a stirring bar, 158c (300 mg, 0.689 mmol), boronic ester 111a (365 mg, 0.758 mmol), Pd(PPh3)4 (39.8 mg, 0.034 mmol), Na2CO3 aqueous solution (1.0 N, 2.27 mL. 2.27 mmol), 1,2-dimethoxyethane (3.0 mL) were added. The mixture was reacted in microwave at 130° C. for 10 min. methylene chloride (200 mL) was added and the resulting mixture was washed with water (30 mL×3), brine (30 mL×1), dried over MgSO4, filtered, and removed solvent in vacuo. Silica gel column chromatography (MeOH:methylene chloride=5:95) gave 158d.

1. customTo a microwave tube equipped with a stirring bar
2. additionwas added
3. washthe resulting mixture was washed with water (30 mL×3), brine (30 mL×1)
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customremoved solvent in vacuo