1,4-Dioxane hydrochloride → HCID 58043654, compound

HRID 1918919Notes

Reaction equation

HRID 1918919 reaction equation
[C:1]([O:4][CH2:5][C:6]1[C:11]([N:12]2[C:24](=[O:25])[C:23]3[S:22][C:21]4[CH2:20][CH2:19][CH2:18][CH2:17][C:16]=4[C:15]=3[CH2:14][CH2:13]2)=[CH:10][C:9]([F:26])=[CH:8][C:7]=1[C:27]1[CH:32]=[C:31]([N:33]([C:41]2[CH:45]=[C:44]([CH:46]3[CH2:49][NH:48][CH2:47]3)[NH:43][N:42]=2)C(OC(C)(C)C)=O)[C:30](=[O:50])[N:29]([CH3:51])[CH:28]=1)(=[O:3])[CH3:2].Cl.O1CCOCC1>O1CCOCC1>[C:1]([O:4][CH2:5][C:6]1[C:11]([N:12]2[C:24](=[O:25])[C:23]3[S:22][C:21]4[CH2:20][CH2:19][CH2:18][CH2:17][C:16]=4[C:15]=3[CH2:14][CH2:13]2)=[CH:10][C:9]([F:26])=[CH:8][C:7]=1[C:27]1[CH:32]=[C:31]([NH:33][C:41]2[CH:45]=[C:44]([CH:46]3[CH2:47][NH:48][CH2:49]3)[NH:43][N:42]=2)[C:30](=[O:50])[N:29]([CH3:51])[CH:28]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86661239HCID 86661239, compound

Product 1

HCID 58043654HCID 58043654, compoundYield 20%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 164e (300 mg, 0.42 mmol) in dioxane (2 mL) at room temperature was added HCl/dioxane (4M, 6 mL) dropwise. The reaction mixture was stirred for 1 h. After the reaction was finished, it was concentrated to afford 164f (crude product) as a black solid, which was used in the next step without purification. LCMS: (M+H)+ 617

Workup

  1. concentrationit was concentrated

Sources & evidence

ORD record
ord-18004546eda84ed9acc6aa30513cc1da
Source dataset
uspto-grants-2013_12
Patent number
US08618107B2

Reaction notes

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