HRID1918944

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)OCc1c(B2OC(C)(C)C(C)(C)O2)cccc1N1CCc2c(sc3c2CCCC3)C1=O

HCID58043718

未命名化合物

HCID58044102

未命名化合物

PRODUCTS

生成物

结构：COCc1cc(Nc2cc(-c3cccc(N4CCc5c(sc6c5CCCC6)C4=O)c3COC(C)=O)cn(C)c2=O)nn1C

HCID68096326

未命名化合物

收率 70%

PROCEDURE

实验过程

Following Example 176d, 327 mg of 5-bromo-3-(5-(methoxymethyl)-1-methyl-1H-pyrazol-3-ylamino)-1-methylpyridin-2(1H)-one 176b and 481 mg of 111a were reacted to give 177a as a yellow solid (420 mg, 70%). LCMS: [M+H]+ 602

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f4289798919744058f19539e61e26994
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08618107B2
来源说明: uspto-grants-2013_12

反应 SMILES

Br[C:2]1[CH:3]=[C:4]([NH:10][C:11]2[CH:15]=[C:14]([CH2:16][O:17][CH3:18])[N:13]([CH3:19])[N:12]=2)[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.[C:20]([O:23][CH2:24][C:25]1[C:30](B2OC(C)(C)C(C)(C)O2)=[CH:29][CH:28]=[CH:27][C:26]=1[N:40]1[CH2:45][CH2:44][C:43]2[C:46]3[CH2:52][CH2:51][CH2:50][CH2:49][C:47]=3[S:48][C:42]=2[C:41]1=[O:53])(=[O:22])[CH3:21]>>[C:20]([O:23][CH2:24][C:25]1[C:26]([N:40]2[C:41](=[O:53])[C:42]3[S:48][C:47]4[CH2:49][CH2:50][CH2:51][CH2:52][C:46]=4[C:43]=3[CH2:44][CH2:45]2)=[CH:27][CH:28]=[CH:29][C:30]=1[C:2]1[CH:3]=[C:4]([NH:10][C:11]2[CH:15]=[C:14]([CH2:16][O:17][CH3:18])[N:13]([CH3:19])[N:12]=2)[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1)(=[O:22])[CH3:21]