HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1918976Generated: October 31, 2026
1,4-Dioxane hydrochloride → 3-(5-(Azetidin-3-yloxy)pyridin-2-ylamino)-5-bromo-1-methylpyridin-2(1H)-one Hydrochloride
https://huagongshe.com/reaction/1918976
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | tert-Butyl 3-(6-(5-Bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)pyridin-3-yloxy)azetidine-1-carboxylate | HCID 58043697 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(5-(Azetidin-3-yloxy)pyridin-2-ylamino)-5-bromo-1-methylpyridin-2(1H)-one Hydrochloride | HCID 86661248 | 100% |
Reaction Steps
A mixture of 199d (1.46 g, 3.2 mmol) and HCl/1,4-dioxane (3.2 mL, 12.8 mmol, 4 M) in methanol (20 mL) was heated at 80° C. for 1 h. The mixture was concentrated under reduced pressure to give 199e (1.24 g, 99%). MS: [M+H]+ 351.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618107B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-f74a269816224b28a56e5113aea5a216 |
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| Source note | uspto-grants-2013_12 |
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