HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-(6-Nitropyridin-3-yl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 5-Bromo-2-nitropyridine | HCID 817620 | — |
| Reactant | Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate | HCID 11243758 | — |
| Product | 4-(6-Nitropyridin-3-yl)morpholine | HCID 2927973 | — |
Reaction Steps
Following the procedures as described for 188a and starting with 2 g of 5-bromo-2-nitropyridine and 968 mg morpholine, 255a was obtained as a yellow solid (1 g, 50%). MS: [M+H]+ 210. 1H NMR (500 MHz, CDCl3) δ 8.18 (d, J=9.0, 1H), 8.15 (d, J=3.0, 1H), 7.22 (dd, J=3.0, 1H), 3.90 (t, J=5.0, 4H), 3.42 (t, J=5.0, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618107B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-40bde261fdb1458ca8082045b65c3060 |
| Source note | uspto-grants-2013_12 |