HRID1919061

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCN1CC(c2ccc(Nc3cc(Br)cn(C)c3=O)nc2)C1

HCID58044141

未命名化合物

结构：CC(=O)OCc1c(B2OC(C)(C)C(C)(C)O2)cc(F)cc1N1CCc2c(sc3c2CC(C)(C)C3)C1=O

HCID67016224

未命名化合物

PRODUCTS

生成物

结构：CCN1CC(c2ccc(Nc3cc(-c4cc(F)cc(N5CCc6c(sc7c6CC(C)(C)C7)C5=O)c4COC(C)=O)cn(C)c3=O)nc2)C1

HCID68208433

未命名化合物

收率 37%

PROCEDURE

实验过程

Following Example 136a, starting with 5-bromo-3-(5-(1-ethylazetidin-3-yl)pyridin-2-ylamino)-1-methylpyridin-2(1H)-one 250a and (2-{4,4-dimethyl-9-oxo-7-thia-10-azatricyclo[6.4.0.02,6]dodeca-1(8),2(6)-dien-10-yl}-4-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl acetate 247b, compound 257a was obtained in 37% yield.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bcbab38bd9bc40b4b89c7ea9abe3e668
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08618107B2
来源说明: uspto-grants-2013_12

反应 SMILES

Br[C:2]1[CH:3]=[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]3[CH2:20][N:19]([CH2:21][CH3:22])[CH2:18]3)=[CH:13][N:12]=2)[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.[C:23]([O:26][CH2:27][C:28]1[C:33](B2OC(C)(C)C(C)(C)O2)=[CH:32][C:31]([F:43])=[CH:30][C:29]=1[N:44]1[CH2:55][CH2:54][C:53]2[C:52]3[CH2:51][C:50]([CH3:57])([CH3:56])[CH2:49][C:48]=3[S:47][C:46]=2[C:45]1=[O:58])(=[O:25])[CH3:24]>>[C:23]([O:26][CH2:27][C:28]1[C:33]([C:2]2[CH:3]=[C:4]([NH:10][C:11]3[CH:16]=[CH:15][C:14]([CH:17]4[CH2:20][N:19]([CH2:21][CH3:22])[CH2:18]4)=[CH:13][N:12]=3)[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=2)=[CH:32][C:31]([F:43])=[CH:30][C:29]=1[N:44]1[CH2:55][CH2:54][C:53]2[C:52]3[CH2:51][C:50]([CH3:57])([CH3:56])[CH2:49][C:48]=3[S:47][C:46]=2[C:45]1=[O:58])(=[O:25])[CH3:24]