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HRID1919090

反应详情

EQUATION

反应方程式

HRID 1919090 的结构方程式

REACTANTS

反应物

2
结构：CN(C)CCN(C)c1ccc(Nc2cc(B3OC(C)(C)C(C)(C)O3)cn(C)c2=O)nc1
HCID58043680

未命名化合物

结构：CC(=O)OCc1c(Br)cc(F)cc1N1CCc2c(sc3c2CCCC3)C1=O
HCID58043756

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)CCN(C)c1ccc(Nc2cc(-c3cc(F)cc(N4CCc5c(sc6c5CCCC6)C4=O)c3CO)cn(C)c2=O)nc1
HCID67016362

未命名化合物

收率 8%

PROCEDURE

实验过程

Following Example 270, reaction of 212a (550 mg, 1.20 mmol) and 270d (428 mg, 1.00 mmol) afforded a 8% yield (49 mg) of 286 as an off-white solid: mp 122-123° C.; 1H NMR (500 MHz, DMSO-d6) d 8.45 (d, 1H, J=2.0 Hz), 8.20 (s, 1H), 7.69 (d, 1H, J=2.4 Hz), 7.31 (m, 2H), 7.17 (m, 3H), 4.83 (t, 1H, J=4.6 Hz), 4.32 (d, 2H, J=4.3 Hz), 4.06 (m, 1H), 3.87 (m, 1H), 3.58 (s, 3H), 2.96 (m, 1H), 2.86 (m, 1H), 2.83 (s, 3H), 2.78 (m, 2H), 2.54 (m, 1H), 2.32 (t, 2H, J=7.0 Hz), 2.14 (s, 6H), 1.80 (m, 4H); MS (ESI+) m/z 631.3 (M+H).