HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron → HCID 67016307, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron | HCID 5462311 | — |
| Reactant | HCID 58044104 | HCID 58044104 | — |
| Reactant | HCID 58044170 | HCID 58044170 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67016307 | HCID 67016307 | 44.8% |
Reaction Steps
Following Example 306b, 307a (422 mg, 1.26 mmol) was converted to the boron intermediate 307b, which was coupled under Suzuki conditions with 109a (420 mg, 1.0 mmol). The crude product was purified via column chromatography: ISCO 24 g silica, 50-100% ethyl acetate/hexanes then 0-10% MeOH, to give 307c (285 mg, 36% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618107B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-5009a4e3c18649fa951137894ef9c3db |
| Source note | uspto-grants-2013_12 |