Hydroxyamine hydrochloride → HCID 58044204, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of NH2OH.HCl (18.4 g, 266 mmol) in MeOH (600 mL) at 0° C. was slowly added CH3COONa (21.8 g, 266 mmol). After stirring at 0° C. for 30 min, 329d (10 g, 53 mmol) was added. The reaction solution was allowed to warm to room temperature and stirred for overnight. It was then evaporated in vacuo. 100 mL of water was added to the residue and the resulting mixture was extracted with ethyl acetate (500 mL×3). The organic layers were combined, washed with brine (50 mL), and dried over sodium sulfate. The drying agent was removed by filtration and the filtrate was concentrated under reduced pressure to give 329e as a yellow solid (10 g, 92%). MS: [M+H]+ 203.

Provenance & Evidence