HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(4-Methylpiperazin-1-yl)pyridin-3-amine → HCID 58044167, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(4-Methylpiperazin-1-yl)pyridin-3-amine | HCID 2763390 | — |
| Reactant | 3,5-Dibromo-1-methyl-1H-pyrazin-2-one | HCID 13062969 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 58044167 | HCID 58044167 | 30% |
Reaction Steps
A mixture of 6-(4-methylpiperazin-1-yl)pyridin-3-amine (1 g, 5.2 mmol) prepared according to US 2009/0318448, 3,5-dibromo-1-methylpyrazin-2(1H)-one (1.7 g, 6.2 mmol), and isopropanol (20 mL) was stirred at reflux for 16 h. After the reaction was completed, the solvent was removed to give 331a as a brown solid (500 mg, 30%). MS: [M+H]+ 379.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618107B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-540ad534e8684640b9cc404853b7573e |
| Source note | uspto-grants-2013_12 |