反应详情

A suspension of 334d (4.0 g, 16 mmol) and Raney Ni (400 mg) in methanol (60 mL) was hydrogenated in a Parr apparatus at 50 psi for overnight. The mixture was filtered through a pad of Celite and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography eluting with 20:1 methylene chloride/methanol to give 334e as a yellow solid (2 g, 50%). MS: [M+H]+ 249.

1. filtrationThe mixture was filtered through a pad of Celite
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue was purified by column chromatography
4. washeluting with 20:1 methylene chloride/methanol