3,5-Dibromo-1-methylpyridin-2(1H)-one → HCID 58043874, compound

HRID 1919152Notes

Reaction equation

HRID 1919152 reaction equation
Br[C:2]1[C:3](=[O:10])[N:4]([CH3:9])[CH:5]=[C:6]([Br:8])[CH:7]=1.[NH2:11][C:12]1[N:17]=[CH:16][C:15]([N:18]2[CH2:22][CH:21]3[CH2:23][N:24]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:25][CH:20]3[CH2:19]2)=[CH:14][CH:13]=1>>[Br:8][C:6]1[CH:7]=[C:2]([NH:11][C:12]2[N:17]=[CH:16][C:15]([N:18]3[CH2:19][CH:20]4[CH2:25][N:24]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:23][CH:21]4[CH2:22]3)=[CH:14][CH:13]=2)[C:3](=[O:10])[N:4]([CH3:9])[CH:5]=1

Participants

3

Reactant 2

HCID 36143503,5-Dibromo-1-methylpyridin-2(1H)-oneHCID 58044251HCID 58044251, compound

Product 1

HCID 58043874HCID 58043874, compoundYield 60%

Procedure

Following Example 188c, 3,5-dibromo-1-methylpyridin-2(1H)-one (212 mg, 0.79 mmol) and 335b (200 mg, 0.66 mmol) were reacted to give 335c as a yellow solid (194 mg, 60%). MS: [M+H]+ 492

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d191c3737ffe42f3a5d855cd1fa52c82
Source dataset
uspto-grants-2013_12
Patent number
US08618107B2

Reaction notes

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