Trifluoroacetic acid → HCID 178437134, compound

Participants

Reaction Steps

TFA (0.25 mL, 3.2 mmol) was added to a stirring solution of (S)-tert-butyl 2-(5-((4′-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)biphenyl-4-yl)ethynyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (17.8 mg) in DCE (1 mL) and stirred at rt for 1 h. The crude reaction was concentrated to yield a TFA salt of 2-((S)-pyrrolidin-2-yl)-5-((4′-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)biphenyl-4-yl)ethynyl)-1H-imidazole (24 mg).

Provenance & Evidence