反应详情

After the reaction liquid had been adjusted to a pH of 13 by the addition of 5 N aqueous solution of sodium hydroxide, N-benzyl-3-aminopiperidine was extracted with 1 L of toluene, and was then further extracted from the aqueous phase with 1 L of toluene. After the solvent had been distilled under reduced pressure away from a combination of the organic phases thus obtained, (R)—N-benzyl-3-aminopiperidine was purified by distillation. Thus, 17.7 g of (R)—N-benzyl-3-aminopiperidine were obtained in the form of colorless oil.

1. customAfter the reaction liquid
2. extractionwas extracted with 1 L of toluene
3. extractionwas then further extracted from the aqueous phase with 1 L of toluene
4. distillationAfter the solvent had been distilled under reduced pressure away from a combination of the organic phases
5. customthus obtained
6. distillation(R)—N-benzyl-3-aminopiperidine was purified by distillation