HCID 58214416, compound → HCID 25030825, compound

HRID 1919278Notes

Reaction equation

HRID 1919278 reaction equation
[C:1]([C:5]1[N:9]=[C:8]([O:10][C:11]2[C:16]([CH3:17])=[CH:15][C:14]([N:18]=[CH:19][N:20]([CH:22](C)[CH3:23])[CH3:21])=[C:13]([CH3:25])[CH:12]=2)[S:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].C(C1N=C(OC2C(C)=CC(/N=C/N3CCCCC3)=C(C)C=2)SN=1)(C)(C)C.C(C1N=C(OC2C(C(F)(F)F)=CC(/N=C/N3CCCCC3)=C(C)C=2)SN=1)(C)(C)C.C(C1N=C(OC2C(C(F)(F)F)=CC(N=CN(CC)C)=C(C)C=2)SN=1)(C)(C)C.C(C1N=C(OC2C(C(F)(F)F)=CC(N=CN(C(C)C)C)=C(C)C=2)SN=1)(C)(C)C.C(C1N=C(OC2C(Cl)=CC(N=CN(C(C)C)C)=C(C)C=2)SN=1)(C)(C)C.C(C1N=C(OC2C(Cl)=CC(N=CN(CC)C)=C(C)C=2)SN=1)(C)(C)C.C(C1N=C(OC2C(Cl)=CC(/N=C/N3CCCCC3)=C(C)C=2)SN=1)(C)(C)C>>[C:1]([C:5]1[N:9]=[C:8]([O:10][C:11]2[C:16]([CH3:17])=[CH:15][C:14]([N:18]=[CH:19][N:20]([CH2:22][CH3:23])[CH3:21])=[C:13]([CH3:25])[CH:12]=2)[S:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

9

Reactant 8

HCID 58214416HCID 58214416, compoundHCID 66840754HCID 66840754, compoundHCID 67497215HCID 67497215, compoundHCID 67497388HCID 67497388, compoundHCID 67497715HCID 67497715, compoundHCID 178428883HCID 178428883, compoundHCID 178428884HCID 178428884, compoundHCID 178428885HCID 178428885, compound

Product 1

HCID 25030825HCID 25030825, compound

Procedure

(A-2) N′-{4-[(3-(tert-butyl)-1,2,4-thiadiazol-5-yl)oxy]-2,5-dimethylphenyl}-N-isopropyl-N-methylimidoformamide; (A-3) 4-[(3-(tert-butyl)-1,2,4-thiadiazol-5-yl)oxy]-2,5-dimethyl-N-[(1E)-piperidin-1-ylmethylene]aniline; (A-4) 4-[(3-(tert-butyl)-1,2,4-thiadiazol-5-yl)oxy]-2-methyl-N-[(1E)-piperidin-1-ylmethylene]-5-(trifluoromethyl)aniline; (A-5) N′-{4-[(3-(tert-butyl)-1,2,4-thiadiazol-5-yl)oxy]-2-methyl-5-(trifluoromethyl)phenyl}-N-ethyl-N-methylimidoformamide; (A-6) N′-{4-[(3-(tert-butyl)-1,2,4-thiadiazol-5-yl)oxy]-2-methyl-5-(trifluoromethyl)phenyl}-N-isopropyl-N-methylimidoformamide; (A-7) N′-{4-[(3-(tert-butyl)-1,2,4-thiadiazol-5-yl)oxy]-5-chloro-2-methylphenyl}-N-isopropyl-N-methylimidoformamide; (A-8) N′-{4-[(3-(tert-butyl)-1,2,4-thiadiazol-5-yl)oxy]-5-chloro-2-methylphenyl}-N-ethyl-N-methylimidoformamide; (A-9) 4-[(3-(tert-butyl)-1,2,4-thiadiazol-5-yl)oxy]-5-chloro-2-methyl-N-[(1E)-piperidin-1-ylmethylene]aniline.

Sources & evidence

ORD record
ord-94e0e286e61543108db91a2528e98920
Source dataset
uspto-grants-2012_05
Patent number
US08168567B2

Reaction notes

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