Diethylamine → HCID 12179642, compound

Participants

Reaction Steps

To stirred and cooled (0° C.) methyl 2-isocyanoacetate (96% technical grade, 2.51 g, 25.36 mmol) was slowly added diethylamine (2.78 g, 38.04 mmol). The mixture was stirred for 16 h at 52° C. and then concentrated. The resulting oil was co-evaporated twice with CH2Cl2:hexane, and purified using column chromatography (SiO2, eluent cyclohexane:EtOAc=6:4) to yield after evaporation and drying N3N-diethyl-2-isocyanoacetamide, SLA 19136, as a brown oil (890 g, 25% yield).

Provenance & Evidence