Hydrochloric Acid → HCID 44183535, compound

Participants

Reaction Steps

A solution of (1S,2R)-2-(tert-butoxycarbonylamino)-1-(4-fluorophenyl)-3-oxo-3-(pyrrolidin-1-yl)propyl acetate, CCH 23140-2 (104 mg, 264 μmol), in Et2O (20 mL) in a 100 mL round-bottomed flask equipped with a magnetic stirbar was stirred for 1 h at RT in presence of a stream of HCl. The reaction mixture was concentrated and dried for 3 days under vacuum to obtain (1S,2R)-2-amino-1-(4-fluorophenyl)-3-oxo-3-(pyrrolidin-1-yl)propyl acetate hydrochloride, Compound 17, as a white solid (86 mg, 98% yield).

Provenance & Evidence