Diethyl bromomalonate → 5-Thiazolecarboxylic acid, 4-hydroxy-2-methyl-, ethyl ester

Participants

Reaction Steps

To a solution of thioacetamide (17.2 g, 0.229 mol) in toluene (130 mL) was added diethyl bromomalonate (55.0 g, 0.230 mol) and the mixture heated at reflux for 3 h. The reaction mixture was cooled to RT, filtered through Celite, then concentrated in vacuo. The resultant solid was triturated with hexane to give the title compound as a yellow solid (11.0 g, 26%).

Provenance & Evidence