2-Methyl-2-(piperazin-1-yl)propanamide → 2-[4-(5-Chloro-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidin-2-ylmethyl)piperazin-1-yl]isobutyramide

HRID 1919388Notes

Reaction equation

HRID 1919388 reaction equation
C(OC(N1C[CH:14]2[CH:10]([CH2:11][N:12]([CH2:16][C:17]3[S:18][C:19]4[C:24]([N:25]5[CH2:30][CH2:29][O:28][CH2:27][CH2:26]5)=[N:23][C:22]([Cl:31])=[N:21][C:20]=4[N:32]=3)[CH2:13]2)C1)=O)(C)(C)C.[N:33]1([C:39]([CH3:44])([CH3:43])[C:40]([NH2:42])=[O:41])CCNCC1>>[Cl:31][C:22]1[N:23]=[C:24]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[C:19]2[S:18][C:17]([CH2:16][N:12]3[CH2:11][CH2:10][N:33]([C:39]([CH3:44])([CH3:43])[C:40]([NH2:42])=[O:41])[CH2:14][CH2:13]3)=[N:32][C:20]=2[N:21]=1

Participants

3

Reactant 2

HCID 217488412-Methyl-2-(piperazin-1-yl)propanamideHCID 582349375-(5-Chloro-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester

Product 1

HCID 594182222-[4-(5-Chloro-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidin-2-ylmethyl)piperazin-1-yl]isobutyramide

Procedure

The title compounds was prepared according to the method used in the preparation of 5-(5-chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester using 2-piperazin-1-yl-isobutyramide in place of hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester. The title compound was obtained as an off-white solid (71 mg, 36%).

Workup

  1. customThe title compounds was prepared

Sources & evidence

ORD record
ord-334207a6902e49b092a118afd390dc7a
Source dataset
uspto-grants-2012_05
Patent number
US08168633B2

Reaction notes

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