HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → (Methylethoxycarbonyloxy)methyl (2R)-4-[(3-azidopropyl)sulfonyloxy]-3,3-dimethyl-2-(phenylmethoxy)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | (Methylethoxycarbonyloxy)methyl (2R)-4-[(3-chloropropyl)sulfonyloxy]-3,3-dimethyl-2-(phenylmethoxy)butanoate | HCID 86628889 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (Methylethoxycarbonyloxy)methyl (2R)-4-[(3-azidopropyl)sulfonyloxy]-3,3-dimethyl-2-(phenylmethoxy)butanoate | HCID 86628890 | — |
Reaction Steps
Following the general procedure for the preparation of azides of Description 16, (methylethoxycarbonyloxy)methyl (2R)-4-[(3-chloropropyl)sulfonyloxy]-3,3-dimethyl-2-(phenylmethoxy)butanoate (27a) (0.14 g, 0.28 mmol) dissolved in 3 mL of anhydrous dimethyl sulfoxide (DMSO) was reacted with 45 mg (0.7 mmol) of sodium azide (NaN3). After work-up, the crude title compound (27) was used in the next step without further purification. MS (ESI) m/z 524.06 (M+Na)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168617B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-bebf569e23554b4aa753855bb6c94dd3 |
| Source note | uspto-grants-2012_05 |