HCID 67499481, compound → HCID 86628917, compound

Participants

Reaction Steps

Following the general procedure for the preparation of acyloxyalkyl/alkoxycarbonyloxyalkyl carboxylic esters from carboxylic acids of Description 22, (2R)-4-{[3-(acetylamino)propyl]sulfonyloxy}-3,3-dimethyl-2-(phenylmethoxy)butanoic acid (17) (0.8 g, 2.0 mmol) dissolved in 12 mL of anhydrous toluene was reacted with 1.4 g (6.0 mmol) of 1-chloroethyl 2-(phenylmethoxy)acetate (25) in the presence of 1.1 g (4.0 mmol) of silver carbonate (Ag2CO3). After work-up and further purification by mass-guided preparative HPLC, 0.1 g (8.4% yield) of the title compound (45a) was obtained as a colorless, viscous oil. MS (ESI) m/z 594.15 (M+H)+, 616.20 (M+Na)+.

Provenance & Evidence