Methyl 5-amino-2,3-dihydrobenzofuran-2-carboxylate → N4-(3-chloro-4-methoxyphenyl)-5-fluoro-N2-[2,3-dihydro-2-(methoxycarbonyl)benzofuran-5-yl]-2,4-pyrimidinediamine

HRID 191946Notes

Reaction equation

HRID 191946 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([F:18])[c:6]([NH:8][c:9]2[cH:10][c:11]([Cl:17])[c:12]([O:15][CH3:16])[cH:13][cH:14]2)[n:7]1.[NH2:19][c:20]1[cH:21][cH:22][c:23]2[c:24]([cH:32]1)[CH2:25][CH:26]([C:28](=[O:29])[O:30][CH3:31])[O:27]2>>[c:2]1([NH:19][c:20]2[cH:21][cH:22][c:23]3[c:24]([cH:32]2)[CH2:25][CH:26]([C:28](=[O:29])[O:30][CH3:31])[O:27]3)[n:3][cH:4][c:5]([F:18])[c:6]([NH:8][c:9]2[cH:10][c:11]([Cl:17])[c:12]([O:15][CH3:16])[cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 22060823Methyl 5-amino-2,3-dihydrobenzofuran-2-carboxylateHCID 220611152-chloro-N4-(3-chloro-4-methoxyphenyl)-5-fluoro-4-pyrimidineamine

Product 1

HCID 22060741N4-(3-chloro-4-methoxyphenyl)-5-fluoro-N2-[2,3-dihydro-2-(methoxycarbonyl)benzofuran-5-yl]-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-a74ac6808a6c402e80e4d242d56d26d7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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