Water → N-(4'-chlorobiphenyl-2-yl)-3-trifluoromethyl-pyrazine-2-carboxamide

Participants

Reaction Steps

Triethylamine (0.32 g: 1.5 mmole) was added to a solution of 4′-chlorobiphenyl-2-ylamine (0.3 g: 1.5 mmole) and 3-trifluoromethylpyrazine-2-carboxylic acid chloride (0.32 g: 1.5 mmole) in THF (10 mL), followed by stirring at room temperature for 2 hours. Water was added to the reaction mixture to suspend the reaction, followed by extraction with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated in vacuo, and the residue was purified by silica gel column chromatography to give the subject compound (0.47 g).

Provenance & Evidence