HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(Chloromethyl)-9h-pyrido[3,4-b]indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Hydroxymethyl-beta-carboline | HCID 5353338 | — |
| Product | 3-(Chloromethyl)-9h-pyrido[3,4-b]indole | HCID 20148409 | — |
Reaction Steps
The 3-(hydroxymethyl)-β-carboline was added to an excess (3 grams) of thionyl chloride and the mixture was refluxed for 1 hour. The excess thionyl chloride was then evaporated and the obtained residue was crystallized from hexane. 2.5 grams of 3-(chloromethyl)-β-carboline was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168639B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-5d11e22d74824925ab9ddf3de0b4e743 |
| Source note | uspto-grants-2012_05 |