反应详情

To a solution of ethyl-3-(5′-fluoro-2′-methoxybenzyl)acrylate (2.36 g, 10.0 mmol) in ethanol (100%, 40 mL) under Ar(g) was added Pd/C (10%, 200 mg) very carefully and the flask containing the mixture was evacuated and purged with H2 three time each. Then a balloon was attached to the flask and the reaction was allowed to go for 15 h at room temperature. The reaction mixture was filtered through a pad of silica eluted with mixed solvent of EtOAc and Hexane (1:1). The crude product that obtained by removal of the solvent in vacuo was purified by a flash column chromatography (10% EtOAc in hexane, Rf=0.20) to give the product (2.25 g, 95%).

1. additionthe flask containing the mixture
2. customwas evacuated
3. custompurged with H2 three time each
4. filtrationThe reaction mixture was filtered through a pad of silica
5. washeluted with mixed solvent of EtOAc and Hexane (1:1)
6. customThe crude product that obtained by removal of the solvent in vacuo
7. customwas purified by a flash column chromatography (10% EtOAc in hexane, Rf=0.20)